MATERNAL MICROCHIMERISM: INCREASED IN THE INSULIN POSITIVE COMPARTMENT OF TYPE 1 DIABETES PANCREAS BUT NOT IN INFILTRATING IMMUNE CELLS OR REPLICATING ISLET CELLS.

Maternal microchimerism: increased in the insulin positive compartment of type 1 diabetes pancreas but not in infiltrating immune cells or replicating islet cells.

Maternal microchimeric cells (MMc) transfer across the placenta during pregnancy.Increased levels of MMc have been observed in several autoimmune diseases including type 1 diabetes but their role is unknown.It has been suggested that MMc are 1) effector cells of the immune response, 2) targets of the autoimmune response or 3) play a role in tissue

read more

Delineation of an Isodicentric Y Chromosome in a Mosaic 45,X/46,X,idic(Y)(qter-p11.3:: p11.3-qter) Fetus by SRY Sequencing, G-banding, FISH, SKY and Study of Distribution in Different Tissues

Many factors such as genetic, developmental and hormonal are involved in mammalian sex determination.The relative importance and the mutual interactions among those factors are obscure.Study of cytogenetic mosaicism involving sex chromosomes may help to further unravel the mysterious process.We report a fetus with a mosaic karyotype, 45,X/46,X,idic

read more

Systems Biology Approaches for the Prediction of Possible Role of Chlamydia pneumoniae Proteins in the Etiology of Lung Cancer.

Accumulating evidence has recently supported the association of bacterial infection with the growth back roads clothing and development of cancers, particularly in organs that are constantly exposed to bacteria such as the lungs, colon, cervical cancer etc.Our in silico study on the proteome of Chlamydia pneumoniae suggests an unprecedented idea of

read more

Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies

Abstract Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the worst prognoses, with no targeted therapeutic strategies currently available.Regulated cell death c6 corvette door handle (RCD), also known as programmed cell death (PCD), has been widely reported to have numerous links to the progression and therapy o

read more